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Ion channel modulators
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Ligand-gated ion channels
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Acid sensing ion channels
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WRPRFa
WRPRFa
Cat. No. AS-020
Structure:
H-Trp-Arg-Pro-Arg-Phe-NH2
Activity:
Acid-sensing ion channel 3 (ASIC3) activator
WRPRFa is a peptide generated from a panel based on the ASIC3 modulating tetrapeptide RPRFa, by introducing changes at each each amino acid to understand their contribution to RPRFa activity. WRPRFa is the most potent ASIC3 activator to date, and has a specific intermolecular contact with the channel. WRPRFa stabilizes the activated state of ASIC3, increasing its sensitivity to protons and effectively removes acute desensitisation. ASIC3 can undergo tachyphylaxis at very acidic pH, which is accelerated by WRPRFa. WRPRFa is a selective and effective in vitro tool to study the interaction of RFamides and ASICs, and by extension gating mechanisms and the biophysics and biology of ASIC3.
Chien et al (2025) Identification, characterization, and structure-activity relationship of the ASIC3-selective peptide WRPRFa. Commun Chem 8 407 https://doi.org/10.1038/s42004-025-01786-7
Related areas
Technical Data
| Structure | H-Trp-Arg-Pro-Arg-Phe-NH2 |
| Molecular Weight | 759.92 |
| Formula | C37H53N13O5 |
| Sequence | H-WRPRF-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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