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Products
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- Resources
SPA4 peptide
Cat. No. TL-010
Structure:
H-Gly-Asp-Phe-Arg-Tyr-Ser-Asp-Gly-Thr-Pro-Val-Asn-Tyr-Thr-Asn-Trp-Tyr-Arg-Gly-Glu-OH
Activity:
TLR4 interacting peptide
SPA4 peptide is a TLR4 interacting peptide identified from the interface of the surfactant protein-A (SP-A) –TLR4 complex. The interaction between SP-A and TLR4 is important for host defence and SPA4 peptide binding to the activated TLR4 complex suppresses inflammatory responses, inhibiting mRNA and cellular protein levels of pro-interleukin-1β, caspase activity and release of interleukin-1β, without affecting TLR4-induced uptake, processing, and clearance of ligands and pathogens. SPA4 peptide does not bind to the natural TLR4 ligand, LPS, or gram-negative bacteria directly. Intraperitoneally and intratracheally administered SPA4 peptide reduces inflammation, bacterial burden, and associated lung injury in mouse models of LPS induced lung inflammation and pseudomonas aeruginosa induced lung infection.
Ramani and Awasthi (2015) Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli. J Leukoc Biol. 98(6) 1037 PMID: 26254306
Awasthi et al (2020) Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide. BMC Pulm Med. 20(1) 179 PMID: 32576172
Awasthi et al (2021) Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide. Immunohorizons 24 5(8) 659 PMID: 34429343
Related areas
All peptides >
All toll like receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Gly-Asp-Phe-Arg-Tyr-Ser-Asp-Gly-Thr-Pro-Val-Asn-Tyr-Thr-Asn-Trp-Tyr-Arg-Gly-Glu-OH |
| Molecular Weight | 2396.05 |
| Formula | C107H145N29O35 |
| Sequence | GDFRYSDGTPVNYTNWYRGE |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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