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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
rytvela
Cat. No. CY-030
Structure:
H-(D)Arg-(D)Tyr-(D)Thr-(D)Val-(D)Glu-(D)Leu-(D)Ala-OH
Other Names:
101.10
Activity:
IL-1 receptor allosteric antagonist
Rytvela is an all D peptide derived from an extracellular loop region of the interleukin-1 receptor accessory protein (IL-1RAcP), which acts as an allosteric negative modulator of the interleukin-1 receptor (IL-1R). In vitro, rytvela is specific, potent and effective and blocks human thymocyte proliferation with an IC50 of 1 nM, Rytvela does not significantly inhibit NF-κB, but instead it selectively inhibits the IL-1R downstream stress associated protein kinases/transcription factor c-jun and Rho GTPase/Rho-associated coiled coil containing protein kinase signaling pathways. In vivo rytvela is active in models of hyperthermia and inflammatory bowel disease and topically in contact dermatitis.
A scrambled control peptide, rytvela scrambled peptide, is also available.
Quiniou et al (2008) Development of a novel noncompetitive antagonist of IL-1 receptor. J Immunol. 180(10) 6977 PMID: 18453620
Dabouz (2020) An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration. J Neuroinflammation. 17(1) 359 PMID: 33246504
Takahashi (2021) Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis. PLoS One 16(9) e0257847 PMID: 34559862
Related areas
All peptides >
All cytokine receptor modulators >
All immunology research areas >
Technical Data
| Structure | H-(D)Arg-(D)Tyr-(D)Thr-(D)Val-(D)Glu-(D)Leu-(D)Ala-OH |
| CAS Number | 868844-53-5 |
| Molecular Weight | 850.96 |
| Formula | C38H62N10O12 |
| Sequence | rytvela |
| Modifications | All amino acids are D isomers |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Safety Data Sheet | CY-030 rytvela SDS_65c50ae944ed1.pdf |
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