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- Resources
FGF7p
Cat. No. RT-030
Structure:
H-Tyr-Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe-Val-Ala-Leu-Asn-Gln-OH
Other Names:
FGF7 peptide, Fibroblast growth factor 7 peptide
Activity:
FGF7 mimetic
FGF7p is a peptide derived from the sequence of fibroblast growth factor 7 (FGF7) that mimics the biological effects of full‐length FGF7. Similar to FGF7, FGF7p drives downstream signaling in urothelium and urothelial cytoprotection, probably through AKT. FGF7p blocks bladder urothelial apoptosis via AKT and its targets, again similarly to FGF7, and mitigates bladder urothelial injury from cyclophosphamide.
Narla et al (2022) FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide. Physiol Rep. 10(7) e15241 PMID: 35388988
Narla et al (2022) Durability of and role of AKT in FGF7p urothelial protection against cyclophosphamide. Physiol Rep. 10(12) e15358 PMID: 35748317
Related areas
All peptides >
All receptor tyrosine kinase modulators >
All regulated cell death research categories >
Technical Data
| Structure | H-Tyr-Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe-Val-Ala-Leu-Asn-Gln-OH |
| Molecular Weight | 2122.99 |
| Formula | C95H138N26O28S |
| Sequence | YASAKWTHNGGEMFVALNQ |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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