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TLQP 21
Cat. No. RT-020
Structure:
H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH
Activity:
VGF derived peptide
TLQP 21 is a peptide named for its four N-terminal amino acids and length, which is derived from the 617 amino acid VGF precursor by proteolytic processing. The target for TLQP 21 is the C3a receptor-1 (C3aR1), a G-protein coupled receptor that is activated by the complement activation product C3a, itself considered a component of innate immunity. TLQP 21 plays a role in the central and peripheral nervous system to regulate feeding, reproductive and circadian behaviours and has a role in neuropathic pain and peripheral adiposity.
Bartolomucci et al (2006) TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci U S A. 103(39) 14584 PMID: 16983076
Hannedouche (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. J Biol Chem. 288(38) 27434 PMID: 23940034
El Gaamouch et al (2020) VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Mol Neurodegeneration 15 4 https://doi.org/10.1186/s13024-020-0357-x
Related areas
All peptides >
All receptor tyrosine kinase modulators >
All immunology research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-OH |
| CAS Number | 869988-94-3 |
| Molecular Weight | 2432.77 |
| Formula | C107H170N40O26 |
| Sequence | TLQPPASSRRRHFHHALPPAR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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