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Products
Pharmacology
Type
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- Technical support
- Resources
KYL
Cat. No. RT-010
Structure:
H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH
Other Names:
EphA4 blocking peptide
Activity:
EphA4 kinase inhibitor
KYL is an EphA4 receptor tyrosine kinase inhibitor with a Kd of 0.8 μM. KYL inhibits EphA4-EphrinA5 interactions with an IC50 of 6.34 μM. Through EphA4 inhibition, KYL can prevent dendritic spine reduction, the blocking of LTP induction and neuronal apoptosis caused by amyloid-β oligomers (AβOs). EphA4-/- neurons or sh-EphA4-transfected neurons showed reduced synaptotoxicity by AβOs. EphA4/c-Abl activation is a key-signalling event that mediates the synaptic damage induced by AβOs.
Lamberto et al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47 PMID: 22489865
Vargas et al (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One 9 e92309 PMID: 24658113
Tamura et al (2020 EphA4 regulates Aβ production via BACE1 expression in neurons. FASEB J. 34(12):16383 PMID: 33090569
Related areas
All peptides >
All receptor tyrosine kinase modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH |
| CAS Number | 676657-00-4 |
| Molecular Weight | 1465.75 |
| Formula | C74H108N14O17 |
| Sequence | KYLPYWPVLSSL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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