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7-Transmembrane receptors
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Melanin concentrating hormone receptors
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Melanin concentrating hormone (human, mouse, rat)
Melanin concentrating hormone (human, mouse, rat)
Cat. No. MH-010
Structure:
H-Asp-Phe-Asp-Met-Leu-Arg-Cys*-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys*-Trp-Gln-Val-OH (disulfide bridge between cyteines 7 and 16)
Other Names:
MCH (human, mouse, rat)
Activity:
Endogenous MCH agonist
Melanin concentrating hormone (human, mouse, rat) is the endogenous agonist at melanin concentration hormone receptors, with IC50 values of 0.3 and 1.5 nM and EC50 values of 3.9 and 0.1 nM at MCH-R1 and MCH-R2 receptors respectively. Melanin concentrating hormone receptors are expressed in the central and peripheral nervous systems and melanin concentrating hormone plays an important role in the control of feeding, energy metabolism, body weight regulation, anxiety, sleep, and reward.
Chung S et al. (2011) Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists. J. Mol. Neurosci. 43 115 PMID:20582487
Diniz and Bittencourt (2017) The Melanin-Concentrating Hormone as an Integrative Peptide Driving Motivated Behaviors. Front Syst Neurosci. 11 32 PMID: 28611599
Diniz and Bittencourt (2019) The Melanin-Concentrating Hormone (MCH) System: A Tale of Two Peptides. Front Neurosci. 13 1280 PMID: 31849590
Related areas
All peptides >
All melanin concentrating hormone receptor modulators >
All endocrinology research categories >
All neuroscience research categories >
All appetite regulation research categories >
Technical Data
| Structure | H-Asp-Phe-Asp-Met-Leu-Arg-Cys*-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys*-Trp-Gln-Val-OH (disulfide bridge between cyteines 7 and 16) |
| CAS Number | 128315-56-0 |
| Molecular Weight | 2386.84 |
| Formula | C105H160N30O26S4 |
| Sequence | DFDMLRCMLGRVYRPCWQV |
| Modifications | Disulfide bridge between cyteines 7 and 16 |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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