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7-Transmembrane receptors
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Peptide receptors
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Vasopressin receptors
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[Arg8]-Vasopressin
[Arg8]-Vasopressin
Cat. No. VR-010
Structure:
H-Cys*-Tyr-Phe-Gln-Asn-Cys*-Pro-Arg-Gly-NH2 (disulphide bridge between cysteines one and six)
Other Names:
Argipressin, AVP, Arginine-8-vasopressin
Activity:
Vasopressin receptor agonist
[Arg8]-Vasopressin is an antidiuretic hormone of hypothalamic origin found in most mammalian species, which is an endogenous agonist for all three subtypes of vasopressin receptor, V1A, V1B and V2. [Arg8]-vasopressin is an important regulator of fluid and electrolyte homeostasis through its anti-diuretic action on the kidney, and is involved in vasodepression and also acts as a neurotransmitter at synapses in the brain where it is involved in cognitive functions including memory.
Thibonnier et al (1991) Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology 129(6) 2845 PMID: 1659517
Mihara et al (1999) [Arg8]-vasopressin-induced increase in intracellular Ca2+ concentration in cultured rat hippocampal neurons. Brain Res Bull. 49(5) 343 PMID: 10452354
Moriya et al (2012) Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 1483 1 PMID: 22975133
Related areas
All peptides >
All vasopressin receptor modulators >
All endocrinology research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Cys*-Tyr-Phe-Gln-Asn-Cys*-Pro-Arg-Gly-NH2 (disulphide bridge between cysteines one and six) |
| CAS Number | 113-79-1 |
| Molecular Weight | 1084.23 |
| Formula | C46H65N15O12S2 |
| Sequence | CYFQNCPRG-NH2 |
| Modifications | Disulfide bridge between cysteines 1 and 6, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.50 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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