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7-Transmembrane receptors
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Neurotensin receptors
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Neurotensin
Neurotensin
Cat. No. NT-010
Structure:
Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
Other Names:
NTS1–13
Activity:
Endogenous neurotransmitter and endocrine modulator
Neurotensin is an endogenous neurotransmitter and hormone, found in both neuronal synaptic vesicles, and in neuroendocrine cells in the periphery. Neurotensin acts through three receptors and is involved in several important biological functions, including analgesia and hypothermia, and also food intake and glucose homeostasis. Neurotensin receptors also have a role in promoting tumour cell proliferation, migration and DNA synthesis. Expression of neurotensin and its receptors has been correlated to cancer prognosis and prediction of treatment.
Vincent et al (1999) Neurotensin and neurotensin receptors. TiPS 20 302 PMID: 10390649
Tyler-McMahon (2000) Neurotensin: peptide for the next millenium. Regul.Pept. 93 125 PMID: 11033059
Mazella et al (2012) Neurotensin and its receptors in the control of glucose homeostasis. Front Endocrinol. 3 143 PMID: 23230428
Li et al (2025) Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging. Exp Mol Med https://doi.org/10.1038/s12276-025-01461-w
Related areas
All peptides >
All neurotensin receptor modulators >
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Technical Data
| Structure | Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH |
| CAS Number | 39379-15-2 |
| Molecular Weight | 1672.94 |
| Formula | C78H121N21O20 |
| Sequence | XLYENKPRRPYIL |
| Modifications | X is Glp |
Solubility and Storage
| Solubility | Soluble to 0.70 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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