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7-Transmembrane receptors
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Formyl peptide receptors
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SHAAGtide
SHAAGtide
Cat. No. FR-040
Structure:
H-Met-Leu-Trp-Arg-Arg-Lys-Ile-Gly-Pro-Gln-Met-Thr-Leu-Ser-His-Ala-Ala-Gly-OH
Activity:
FPRL1 activator
SHAAGtide is a peptide derived from stepwise cleavage from CCL23β, a chemokine product of the alternatively spliced form of the CCL23 gene, by proteases associated with inflammation. The active fragment CCL23β Δ24 is also generated by this process, and is a functional ligand for both CCR1 and FPRL1, whereas SHAAGtide, while equipotent with CCL23β Δ24 on the FPRL1 receptor, is inactive for CCR1. The presence of SHAAGtide appears to be transient as the proinflammatory proteases subsequently cleave within the peptide, abolishing its activity for FPRL1. SHAAGtide has potent signaling and chemoattractant properties in vitro, and is functional in vivo, recruiting leukocytes, including neutrophils, to mouse skin after intradermal injection.
Miao et al (2007) Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. J Immunol. 2007 178(11) 7395 PMID: 17513790
He and Ye RD (2007) The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition. Molecules 22(3) 455 PMID: 28335409
IUPHAR-BPS Guide to Pharmacology - SHAAGtide
Related areas
All peptides >
All Formyl peptide receptor modulators >
All immunology categories >
Technical Data
| Structure | H-Met-Leu-Trp-Arg-Arg-Lys-Ile-Gly-Pro-Gln-Met-Thr-Leu-Ser-His-Ala-Ala-Gly-OH |
| Molecular Weight | 2052.09 |
| Formula | C90H149N29O22S2 |
| Sequence | MLWRRKIGPQMTLSHAAG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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