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Endomorphin-2
Cat. No. MO-020
Structure:
H-Tyr-Pro-Phe-Phe-NH2
Other Names:
EM-2
Activity:
Potent and selective μ opioid receptor agonist
Endomorphin-2 is an endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors, with Ki values of 0.69, 9233 and 5240 nM for μ, δ and κ receptors respectively. Endomorphin-2 is one of the two endomorphins and along with endomorphin-1 produces analgesia in animals, but whereas endomorphin-1 is more prevalent in the brain, endomorphin-2 is more prevalent in the spinal cord.
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
Okutsu et al (2006) Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively. Neuropsychopharmacology 31 375 PMID: 16034447
Rivero et al (2012). Endomorphin-2: a biased agonist at the μ-opioid receptor. Molecular Pharmacology 82(2) 178 PMID: 22553358
Related areas
All peptides >
All μ opioid receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Tyr-Pro-Phe-Phe-NH2 |
| CAS Number | 141801-26-5 |
| Molecular Weight | 571.65 |
| Formula | C32H37N5O5 |
| Sequence | YPFF-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.40 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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