The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Endomorphin-1
Cat. No. MO-010
Structure:
H-Tyr-Pro-Trp-Phe-NH2
Other Names:
EM1
Activity:
Endogenous μ receptor agonist
Endomorphin 1 is an endogenous opioid peptide and one of the two endomorphins. Endomorphin 1 has exceptionally high affinity and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively and may be the actual endogenous ligand of the μ-receptor. Endomorphin 1 is distributed throughout the human, rodent and primate central and peripheral nervous systems, and has a more potent analgesic effect in acute and neuropathic pain than other opiates such as morphine, with fewer side effects.
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
Mehta et al (2001) Endomorphin-1: Induction of Motor Behavior and Lack of Receptor Desensitization. J. Neuroscience 21(12) 4436 PMID: 11404430
Gu et al (2017) Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics. Neurosignals 25 98 PMID: 29132133
Related areas
All peptides >
All μ opioid receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Tyr-Pro-Trp-Phe-NH2 |
| CAS Number | 189388-22-5 |
| Molecular Weight | 610.67 |
| Formula | C34H38N6O5 |
| Sequence | YPWF-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.60 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2025 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio