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Tertiapin LQ
Cat. No. KC-030
Structure:
H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2; disulfide bridges between cysteines 3 - 14 and 5 - 18
Other Names:
TPNLQ, TLQ
Activity:
Selective Kir1.1 blocker
Tertiapin LQ is a selective blocker of Kir1.1 channels, obtained by modifying tertiapin, the toxin from the honey bee venom. Tertiapin LQ blocks Kir1 with high affinity (1.1 nM) and high selectivity (>250-fold) over many commonly studied Kir subtypes. Application of tertiapin LQ locally in the superficial layers of the cerebellar cortex in decerebrate ferrets suppresses normal performance of Purkinje cell pause responses to the conditional stimulus with no detectable effect on spontaneous firing.
Ramu et al (2008) Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc.Natl.Acad.Sci.USA 105 10774 PMID: 18669667
Estrada and Kaufman (2018) µ-Opioid receptors inhibit the exercise pressor reflex by closing N-type calcium channels but not by opening GIRK channels in rats. Am J Physiol Regul Integr Comp Physiol. 314(5) R693 PMID: 29341826
Johansson and Hesslow (2020) Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses. Sci Rep 10 15654 PMID: 32973240
Pubchem entry for tertiapin LQ
Related areas
All peptides >
All potassium channel modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Ala-Leu-Cys*-Asn-Cys*-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys*-Trp-Lys-Lys-Cys*-Gly-Lys-Lys-NH2; disulfide bridges between cysteines 3 - 14 and 5 - 18 |
| Molecular Weight | 2428.03 |
| Formula | C106H179N33O24S4 |
| Sequence | ALCNCNRIIIPLQCWKKCGKK-NH2 |
| Modifications | Disulfide bridges between cysteines 3 - 14, and 5 - 18, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in 20% acetonitrile / water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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