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Myelin Basic Protein (85-99) peptide antagonist

Cat. No. NR-120

Structure:

H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH

Other Names:

J5

Activity:

Candidate autoantigen in multiple sclerosis
Price Qty
1 mg    £ 145.00
MBP (85-99) peptide antagonist, or J5, is a 15 amino acid peptide fragment designed on the binding motif of MBP 85-99 (myelin basic protein 85-99) to HLA-DR2 (human leukocyte antigen-DR2), which competes with and inhibits the binding of MBP (85-99) to HLA-DR2 and IL-2. MBP 85-99 is the the immunodominant epitope of MBP and a major candidate autoantigen in multiple sclerosis (MS), making this peptide a useful tool for MS research.

Smith et al (2005) Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis 102(27) 9595 PMID: 15983366

Stern (2005) Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis 102(5) 1620 PMID: 15665083

Fridkis-Hareli (2013) Design of peptide immunotherapies for MHC Class-II-associated autoimmune disorders. Clin. Dev. Immunol. 2013 826191 PMID: 24324511


Related areas

All myelin peptides >
All epitopes >
All categories for immunology >


Technical Data

Structure H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH
CAS Number 444305-16-2
Molecular Weight 1543.8
Formula C70H114N18O21
Sequence EKPKVEAYKAAAAPA
Modifications None

Solubility and Storage

Solubility Soluble in dilute acid
Appearance Freeze dried solid
Storage Store frozen and desiccated in the dark

Batch Specific Data

Purity >95% by HPLC
Safety Data Sheet Myelin Basic Protein (85-99) peptide antagonist MSDS_602c00c6911b1.pdf

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
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Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
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Italy
Labospace
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Spain and Portugal
Abyntek Biopharma
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Fax: +34 94 404 80 81
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China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

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Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
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07291852429
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Japan

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