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[Leu144, Arg147]-PLP (139-151)

Cat. No. NR-040

Structure:

H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH

Activity:

T cell receptor antagonist
Price Qty
[Leu144, Arg147]-PLP (139-151) is an analogue of PLP (139-151) which can act as a T-cell receptor antagonist, able to prevent development of the autoimmune disease model experimental allergic encephalomyelitis (EAE). [Leu144, Arg147]-PLP (139-151 prevents EAE when co-administered with native PLP(139–151) and can limit progression of EAE if given early after the onset of disease in mice.

Ruiz et al (1999) Suppressive Immunization with DNA Encoding a Self-Peptide Prevents Autoimmune Disease: Modulation of T Cell Costimulation J. Immunol. (1999) 162(6) 3336 PMID: 10092787

Anderton (2001) Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities. Immunology 104(4) 367 PMID: 11899421

Potolicchio et al (2005) Conformational Variation of Surface Class II MHC Proteins during Myeloid Dendritic Cell Differentiation Accompanies Structural Changes in Lysosomal MIIC. J. Immunol. 175 4935 PMID: 16210595


Related data

All myelin peptides >
All immunology research areas >


Technical Data

Structure H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
CAS Number 188859-65-6
Molecular Weight 1467.7
Formula C67H110N20O17
Sequence HSLGKLLGRPDKF
Modifications None

Solubility and Storage

Solubility Soluble in dilute acid
Appearance Freeze dried solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC

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