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Products
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[Ser140]-PLP (139-151)
Cat. No. NR-130
Structure:
H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
Activity:
Induces acute autoimmune encephelomyelitis (EAE)
[Ser140]-PLP (139-151) is a serine substituted PLP (139-151) variant, which can cause acute autoimmune encephelomyelitis (EAE) in mice.
Kalbus et al (2001), Ligand motif of the autoimmune disease‐associated mouse MHC class II molecule H2‐As. Eur. J. Immunol. 31 551 PMID: 11180120
Kiptoo et al (2013) Controlling immune response and demyelination using highly potent bifunctional peptide inhibitors in the suppression of experimental autoimmune encephalomyelitis. Clin. Exp. Immunol. 172(1) 23 PMID: 23480182
Related areas
Technical Data
| Structure | H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH |
| CAS Number | 122018-58-0 |
| Molecular Weight | 1521.8 |
| Formula | C72H104N20O17 |
| Sequence | HSLGKWLGHPDKF |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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