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PLP (139-151)

Cat. No. NR-030

Structure:

H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH

Other Names:

Proteolipid protein (139-151)

Activity:

Induces severe experimental allergic encephalomyelitis (EAE)
Price Qty
PLP (139-151), or proteolipid protein (139-151) is a myelin proteolipid protein (PLP) fragment. PLP is one of the major protein constituents of myelin, along with myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP), which between them make up 15% - 25% of dry weight, the rest being mainly lipids. Myelin has an essential insulating role for nerves, allowing normal motor function, sensory function and cognition. Animals immunized with PLP (139-151) develop severe experimental allergic encephalomyelitis (EAE) and this model is widely used to study human multiple sclerosis (MS).

Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343

Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology 59 305 PMID: 1716908

Tigno-Aranjuez et al (2009) Encephalitogenicity of Complete Freund’s Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells. J. Immunol. 183(9) 5654 PMID: 19812193


Related areas

All myelin peptides >
All immunology research categories >


Technical Data

Structure H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
CAS Number 131334-43-5
Molecular Weight 1537.8
Formula C72H104N20O16S
Sequence HCLGKWLGHPDKF
Modifications None

Solubility and Storage

Solubility Soluble in dilute acid
Appearance Freeze dried solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC

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