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Products
Pharmacology
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- Technical support
- Resources
IRBP (651-670) (human)
Cat. No. IM-050
Structure:
H-Leu-Ala-Gln-Gly-Ala-Tyr-Arg-Thr-Ala-Val-Asp-Leu-Glu-Ser-Leu-Ala-Ser-Gln-Leu-Thr-OH
Other Names:
hIRBP651-670, human IRBP651-670
Activity:
Residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP)
IRBP (651-670) (human), sometimes referred to as hIRBP651-670 or human IRBP651-670, is amino acid residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP), which has been identified as a new uveitogenic epitope. IRBP (651-670) (human) is uveitogenic for mice of the H-2b haplotype and elicits experimental autoimmune uveitis (EAU) with a higher severity and incidence in C57BL/6 mice than the previously characterized IRBP (1-20) (human) epitope. Co-immunization with IRBP (1-20) (human) and IRBP (651-670) human is additive but not synergistic. IRBP (651-670) (human) appears to be an epitope naturally processed from a conserved region of native IRBP.
Mattapallil et al (2015) Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype. Invest. Ophthalmol. Vis. Sci. 56(9) 5439 PMID: 26284549
Zhang et al (2017) Complement Component C4 Regulates the Development of Experimental Autoimmune Uveitis through a T Cell-Intrinsic Mechanism. Front. Immunol. 8 1116 PMID: 28955337
Tan et al (2020) Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. Cell Death Dis. 11 697 PMID: 32829384
Related data
Technical Data
| Structure | H-Leu-Ala-Gln-Gly-Ala-Tyr-Arg-Thr-Ala-Val-Asp-Leu-Glu-Ser-Leu-Ala-Ser-Gln-Leu-Thr-OH |
| Molecular Weight | 2107.35 |
| Formula | C91H151N25O32 |
| Sequence | LAQGAYRTAVDLESLASQLT |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | IRBP (651-670) (human) MSDS_602be303dc8ff.pdf |
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