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Products
Pharmacology
Type
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- Technical support
- Resources
MOG (35-55) (human)
Cat. No. NR-010
Structure:
H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Pro-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
Activity:
Fragment of human myelin oligodendrocyte glycoprotein (MOG)
MOG (35-55) (human) is a truncated fragment of human myelin oligodendrocyte glycoprotein (MOG), the transmembrane glycoprotein expressed at the surface of oligodendrocyte cells and on the outermost surface of the myelin sheath, which can be used for the induction of experimental autoimmune encephalomyelitis in mouse and rat models. In contrast to MOG (35-55) (rat), Mog (35-55) (human) is only weakly encephalitogenic but both induce antibodies that are equivalent in titer and IgG subclass, demonstrating that EAE can be induced in C57BL/6 mice by two different mechanisms
Oliver et al (2003) Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice. J. Immunol. 171 (1) 462 PMID: 12817031
Haas et al (2005) Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur. J. Immunol. 35(11) 3343 PMID: 16206232
Related areas
Technical Data
| Structure | H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Pro-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH |
| CAS Number | 163158-19-8 |
| Molecular Weight | 2592.0 |
| Formula | C120H179N35O28S |
| Sequence | MEVGWYRPPFSRVVHLYRNGK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | MOG (35-55) (human) MSDS_602bfda26be12.pdf |
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