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IRBP (1-20) (human)

Cat. No. IM-040

Structure:

H-Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu- Val- Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp-OH

Activity:

N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP)
Price Qty
1 mg    £ 75.00
IRBP (1-20) (human) is the 1 to 20 amino acid N-terminal fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP, also known as retinol binding protein-3 (RBP-3), is a 1264 amino acid residue glycolipoprotein residing in the interphotoreceptor matrix where it is the major extracellular retinoid-binding protein. IRBP is often the target of autoimmune attack and this is one of the leading causes of uveitis. IRBP peptide (1-20) (human) contains a major epitope for the H-2b haplotype and immunization with IRBP (1–20) (human) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU), a widely used rodent model of human disease.

Avichezer et al (2000) Identification of a New Epitope of Human IRBP that Induces Autoimmune Uveoretinitis in Mice of the H-2b Haplotype. Invest. Ophthalmol. Vis. Sci. 41(1) 127 PMID: 10634611

Fengqi et al (2009) Role of DAF in Protecting against T-Cell Autoreactivity that Leads to Experimental Autoimmune Uveitis. Invest. Ophthalmol. Vis. Sci. 50(8) 3778 PMID: 19443714

Meng et al (2017) Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1–20 in mice. Cell Mol. Immunol. 14 702 PMID: 26996065


Related areas

All epitopes >
All immunology research areas >


Technical Data

Structure H-Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu- Val- Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp-OH
CAS Number 298202-25-2
Molecular Weight 2194.62
Formula C101H164N24O28S
Sequence GPTHLFQPSLVLDMAKVLLD
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store desiccated, frozen and in the dark

Batch Specific Data

Purity >95% by HPLC
Safety Data Sheet IRBP (1-20) (human) MSDS_602be282acf30.pdf

Contact Information

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