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HOXB7 8-25

Cat. No. EP-030

Structure:

H-Pro-Leu-Leu-Leu-Lys-Leu-Leu-Lys-Ser-Val-Gly-Ala-Gln-Lys-Asp-OH

Other Names:

HOXB7(8-25), HOXB7 peptide

Activity:

Targets HOXB7 expressing tumours
Price Qty
1 mg    $ 165.00

HOXB7 8–25 is a novel Homeobox B7 (HOXB7) derived peptide epitope, identified as having the potential to bind to multiple HLA-DRs (DR1, 4, 7, 11, and 15) and target HOXB7 expressing tumours through immune cells.   HOXB7 is a master regulatory gene that regulates cell proliferation and activates oncogenic pathways, and overexpression of HOXB7 correlates with poor prognosis in cancer.   In human head and neck squamous cell carcinoma (HNSCC) tissue HOXB7 8-25 shows direct cytotoxicity and antigen specific and tumour reactive promiscuous CD4+ T cell responses, producing γ-interferon and directly killing tumours through granzyme B.  HOXB7 is thus demonstrated to be a potential target for cancer immunotherapy,

Komatsuda et al (2022) Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation. Cancer Sci. 2022 Epub ahead of print. PMID: 36285482


Related areas

All peptides >
All epitopes >
All immunology research categories >
All cancer research categories >


Technical Data

Structure H-Pro-Leu-Leu-Leu-Lys-Leu-Leu-Lys-Ser-Val-Gly-Ala-Gln-Lys-Asp-OH
Molecular Weight 1622.01
Formula C75H135N19O20
Sequence PLLLKLLKSVGAQKD
Modifications None

Solubility and Storage

Solubility Soluble in DMSO
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

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sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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