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7-Transmembrane receptors
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Galanin receptors
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Galanin (human)
Galanin (human)
Cat. No. GA-020
Structure:
H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH
Other Names:
Galanin (1-30) (human)
Activity:
Endogenous galanin receptor agonist
Galanin (human) is an endogenous peptide with high affinity for all three galanin receptors and multiple endocrine, metabolic and behavioural effects. Named galanin after its N-terminal glycine and its C-terminal alanine, galanin (human) is widely expressed in the central and peripheral nervous system as well as in the endocrine system and co-exists with a number of classical neurotransmitters. Galanin (human) is also linked to cognitive deficits in Alzheimer's disease.
Schmidt et al (1991) Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc.Natl.Acad.Sci.U.S.A. 88 11435 PMID: 1722333
Webling et al (2012) Galanin Receptors and Ligands. Front. Endocrinology 3 146 https://www.frontiersin.org/article/10.3389/fendo.2012.00146
Volpe et al (2020) Is Galanin a Promising Therapeutic Resource for Neural and Nonneural Diseases? Current Drug Targets 21(9) 922 PMID: 32096740
Related areas
All peptides >
All galanin receptor modulators >
All neuroscience research categories >
All endocrinology research categories >
Technical Data
| Structure | H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH |
| CAS Number | 119418-04-1 |
| Molecular Weight | 3155.55 |
| Formula | C139H210N42O43 |
| Sequence | GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 0.50 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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