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Multi-Leu peptide
Cat. No. PI-290
Structure:
Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2
Other Names:
ML-peptide, Multi-Leucine (ML)-peptide
Activity:
PACE4 inhibitor
Multi-Leu peptide is a peptide identified from a partial combinatorial library that is selective for the proprotein convertase PACE4, notably being 20 fold selective over furin, a closely related enzyme with similar structural characteristics. Proprotein convertases play an important role in protein precursor activation through processing at paired basic residues and PACE4 specifically has an important role in prostate cancer. Consistent with inhibition of PACE4, Multi-Leu peptide significantly reduces the proliferation of DU145 and LNCaP prostate cancer derived cell lines and induces G0/G1 cell cycle arrest.
Levesque et al (2012) The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. J Med Chem. 55(23) 10501 PMID: 23126600
Kwiatkowska et al (2019) Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug. Sci Rep. 9(1) 2118 PMID: 30765725
Related areas
All peptides >
All serine protease modulators >
All cancer research categories >
Technical Data
| Structure | Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2 |
| Molecular Weight | 1050.74 |
| Formula | C49H94N16O9 |
| Sequence | Ac-LLLLRVKR-NH2 |
| Modifications | N terminal acetyl, C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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