The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Compstatin
Cat. No. PI-270
Structure:
H-Ile-*Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-*Cys-Thr-NH2 (disulphide bridge between cysteines 2 and 12)
Activity:
C3 convertase inhibitor
Compstatin, a cyclic tridecapeptide, discovered from a phage-display library, is a highly potent and selective complement component 3 (C3) inhibitor, binding to C3, C3b, and C3c, but not to C3d. Compstatin binds to C3 in a reversible manner and inhibits proteolytic cleavage by C3 convertase to the proteins C3a and C3b and consequent activation of classical and alternative complement pathways. Compstatin accordingly acts as a complement inhibitor and prolongs graft survival and reduces hyperacute rejection of pig kidneys perfused with human blood, and inhibits in vivo heparin/protamine induced complement activation in primates.
Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. 157(2) 884 PMID: 8752942
Ricklin and Lambris (2008) Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol. 632 273 PMID: 19025129
Mastellos et al (2015) Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. Eur J Clin Invest. 45(4) 423 PMID: 25678219
Related areas
All peptides >
All serine protease modulators >
All immunology research categories >
Technical Data
| Structure | H-Ile-*Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-*Cys-Thr-NH2 (disulphide bridge between cysteines 2 and 12) |
| CAS Number | 206645-99-0 |
| Molecular Weight | 1550.77 |
| Formula | C66H99N23O17S2 |
| Sequence | ICVVQDWGHHRCT-NH2 |
| Modifications | C-terminal amide, disulphide bridge between cysteines 2 and 12 |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Certificate of Analysis | PI-270-1MG Compstatin Certificaqte of Analysis_667c3005d7e13.pdf |
| Safety Data Sheet | PI-270 Compstatin SDS_667c30d74235d.pdf |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2025 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio