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Products
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- Resources
Sivelestat
Cat. No. PI-180
Structure:
Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
Other Names:
ONO 5046
Activity:
Human neutrophil elastase inhibitor
Sivelestat, also known as ONO 5046, is a competitive inhibitor of human neutrophil elastase with an IC50 of 0.044 μM. Sivelistat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse but does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin or cathepsin G even at 100μM. Sivelistat is used in the treatment of acute respiratory failure and also improves neuropathic pain.
Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Comm. 177(2) 814 PMID: 2049103
Weyer and Stucky (2015) Repurposing a leukocyte elastase inhibitor for neuropathic pain. Nat. Med. 21 429 PMID: 25951529
Related areas
All small molecules >
All serine protease modulators >
All pain research categories >
Technical Data
| Structure | Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid |
| CAS Number | 127373-66-4 |
| Molecular Weight | 434.46 |
| Formula | C20H22N2O7S · xNa+ · yH2O |
| Sequence | Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | White solid |
| Storage | Store dry, dark and frozen |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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