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- Resources
TPCK
Cat. No. PI-220
Structure:
N-p-Tosyl-L-phenylalanine chloromethyl ketone
Activity:
Irreversible chymotrypsin-like serine protease inhibitor
TPCK is an irreversible chymotrypsin-like serine protease inhibitor, acting as an alkylating agent that interferes with translation. TPCK is useful for inhibiting chymotrypsin activity in trypsin preparations. TPCK also inhibits apoptosis in thymocytes and blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
Fearnhead et al (1995) A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli, FEBS Lett. 357 242 PMID: 7835420
Griscavage et al (1996) Inhibitors of the Proteasome Pathway Interfere with Induction of Nitric Oxide Synthase in Macrophages by Blocking Activation of Transcription Factor NF-kappa. Proc. Natl. Acad. Sci. USA 93(8) 3308 PMID: 8622934
Related areas
All small molecules >
All serine protease modulators >
All immunology research areas >
Technical Data
| Structure | N-p-Tosyl-L-phenylalanine chloromethyl ketone |
| CAS Number | 402-71-1 |
| Molecular Weight | 351.85 |
| Formula | C17H18ClNO3S |
| Sequence | N-p-Tosyl-L-phenylalanine chloromethyl ketone |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | White solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | ≥98% by TLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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