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Mca-YVADAP-K(Dnp)-OH
Cat. No. PS-030
Structure:
Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH
Other Names:
Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH
Activity:
FRET substrate for caspase-1
Mca-YVADAP-K(Dnp)-OH, or Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, is a highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp)-OH at the P1 Asp residue results in a continuous fluorescent assay which can be monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Mca-YVADAP-K(Dnp)-OH is a specific substrate for renal ACE 2.
Kondo et al (1997) Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Proc. Natl. Acad. Sci. 94(22) 11951 PMID: 9342343
Bekhouche et al (2010) Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. J. Biol. Chem. 285(21) 15950 PMID: 20207734
Bijakowski et al (2012) Sizzled Is Unique among Secreted Frizzled-related Proteins for Its Ability to Specifically Inhibit Bone Morphogenetic Protein-1 (BMP-1)/Tolloid-like Proteinases. J. Biol. Chem. 287 33581 PMID: 22825851
Related areas
All caspase modulators >
All fluorescent labelled peptides >
All substrate peptides >
Technical Data
| Structure | Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH |
| CAS Number | 189696-01-3 |
| Molecular Weight | 1145.1 |
| Formula | C53H64N10O19 |
| Sequence | Mca-YVADAPK(Dnp) |
| Modifications | 7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 7 |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Mca-YVADAP-K(Dnp)-OH MSDS_602bfb402db95.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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