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DAPT
Cat. No. SC-010
Structure:
N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
Other Names:
LY-374973, γ-Secretase inhibitor IX
Activity:
γ-Secretase inhibitor
DAPT is a γ-secretase inhibitor, which can reduce Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT is also active also in brain extract, cerebrospinal fluid and plasma in vivo, with no no effect on APPα and APPβ levels. DAPT blocks notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and can cause causes embryonic stem cells (ESCs) to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from human pluripotent stem cells (hPSCs) and maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids.
Dovey (2001) Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 76(1) 173 PMID: 11145990
De Smedt et al (2005) Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. Blood 106(10) 3498 PMID: 16030192
Crawford and Roelink (2007) The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling. Dev Dyn. 236(3) 886 PMID: 17295317
Related areas
All small molecules >
All secretase modulators >
All neuroscience research categories >
All stem cell research categories >
Technical Data
| Structure | N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester |
| CAS Number | 208255-80-5 |
| Molecular Weight | 432.46 |
| Formula | C23H26F2N2O4 |
Solubility and Storage
| Solubility | Soluble to 100 mM in DMSO |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by TLC, NMR conforms |
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