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- Technical support
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Pepstatin A
Cat. No. PI-120
Structure:
Isovaleryl-Val-Val-Sta-Ala-Sta
Activity:
Aspartyl peptidase inhibitor
Pepstatin A is an inhibitor of aspartyl peptidases. Pepstatin A is highly selective for proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B and does not inhibit thiol proteases, neutral proteases, or serine proteases. Pepstatin A also inhibits solubilized γ-secretase and retroviral proteases and has been used to characterize proteases from a number of sources.
Umezawa et al (1970) Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J. Antibiot. 23(5) 259 PMID: 4912600
Sato et al (2007) Autophagy Is Activated in Colorectal Cancer Cells and Contributes to the Tolerance to Nutrient Deprivation. Cancer Res. 67(20) 9677 PMID: 17942897
Kania et al (2010) Urinary proteases degrade albumin: implications for measurement of albuminuria in stored samples. Ann. Clin. Biochem. 47(2) 151 PMID: 20150213
Related areas
Technical Data
| Structure | Isovaleryl-Val-Val-Sta-Ala-Sta |
| CAS Number | 26305-03-3 |
| Molecular Weight | 685.89 |
| Formula | C34H63N5O9 |
| Sequence | VVA |
| Modifications | Val-1 =is N-terminal H-iso-Valeryl, Val-2 is Val-4-amino-3-hydroxy-6-methylheptanoyl, Alanine-3 is Ala-4-amino-3-hydroxy-6-methylheptanoic-acid |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in ethanol with gentle warming |
| Appearance | Freeze dried solid |
| Storage | Store dry, dark and frozen |
Batch Specific Data
| Purity | >98% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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