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VPM-p15
Cat. No. OR-020
Structure:
H-Val-Ser-Phe(4-Me)-Gly-Ile-Leu-Leu-Asp-Leu-Ser-Arg-Thr-Ser-Leu-Pro-OH
Other Names:
T1V/F3Phe(4-Me)
Activity:
GPR64 (ADGRG2) agonist
VPM-p15 is an optimised version of the peptide p15, itself an activator derived from the ADGRG2 Stachel sequence, an agonist sequence found within within the large ectodomains of members of the adhesion G protein-coupled receptor (aGPCR) family. VPM-p15 activates ADGRG2 with significantly improved (>2 orders of magnitude) affinity compared to p15. VPM-p15 is a useful tool to investigate the function of ADGRG2, which is a critical regulator of male fertility that maintains ion/pH homeostasis and CFTR coupling.
Sun et al (2021) Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. J Biol Chem. 296 100174 PMID: 33303626
Related areas
All peptides >
All adhesion class receptors >
All endocrinology categories >
Technical Data
| Structure | H-Val-Ser-Phe(4-Me)-Gly-Ile-Leu-Leu-Asp-Leu-Ser-Arg-Thr-Ser-Leu-Pro-OH |
| Molecular Weight | 1631.91 |
| Formula | C75H126N18O22 |
| Sequence | VSXGILLDLSRTSLP |
| Modifications | X is 4-methylphenylalanine |
Solubility and Storage
| Solubility | Soluble in DMSO and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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