The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
LA3IK
Cat. No. PP-550
Structure:
Ac-Leu-Ala-Ile-Ala-Val-Lys-NH2
Other Names:
LAIAVK
Activity:
Disrupts EGFR–ERBB2 heterodimerisation
LA3IK is a novel Migration and Invasion Enhancer 1 (MIEN1) based hexapeptide, which is able to inhibit EGF mediated tumour progression in androgen independent, EGFR overexpressing PC3 prostate cancer cells. LA3IK selectively disrupts EGFR–ERBB2 heterodimerisation, reducing both phosphorylation of EGFR and downstream signaling through NF-κB, Src, and STAT3, leading to impaired EGF-driven migration and invasion while sparing proliferation. Transcriptomic analyses shows downregulation of the angiogenesis related genes ANGPTL4 and VEGFC. Crucially, LA3IK exhibits cancer selectivity, inhibiting EGF signaling in prostate tumours while preserving physiological EGFR function in healthy liver tissue.
Tripathi et al (2026) An MIEN1-based hexamer peptide (LA3IK) inhibits EGF-driven oncogenic signaling in prostate cancer by disrupting EGFR–ERBB2 heterodimerization. Sci Rep https://doi.org/10.1038/s41598-026-41933-1
Related areas
All peptides >
All protein - protein interaction modulators >
All cancer research areas >
Technical Data
| Structure | Ac-Leu-Ala-Ile-Ala-Val-Lys-NH2 |
| Molecular Weight | 654.85 |
| Formula | C31H58N8O7 |
| Sequence | Ac-LAIAVK-NH2 |
| Modifications | N terminal acetyl, C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2026 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio