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Products
Pharmacology
Type
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- Ordering
- About Us
- Technical support
- Resources
Pep63
Cat. No. PP-500
Structure:
H-Val-Phe-Gln-Val-Arg-Ala-Arg-Thr-Val-Ala-OH
Activity:
EphB2 - ADDL interaction inhibitor
Pep63 was identified from an array assay to find peptides able to block the EphB2 – Aβ-derived diffusible ligands (ADDL) interaction. ADDLs are soluble amyloid-β (Aβ) oligomers which constitute a large part of senile plaques and are an important pathogenic factor in Alzheimer's disease (AD). Aβ oligomers bind to the fibronectin (FN) type III repeat domain of EphB2 to trigger EphB2 degradation, impairing the normal functioning of NMDA receptors and resulting in cognitive deficits; consequently blocking the interaction of EphB2 and ADDLs is a potential strategy for early treatment of AD. In cultured hippocampal neurons, Pep63 prevents ADDL induced depletion of EphB2- and GluN2B-containing NMDA receptors and rescues the induced impaired synaptic plasticity. In vivo, Pep63 improves memory deficits in APP/PS1 transgenic mice.
Shi et al (2016) Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease. J Neurosci. 36(47) 11959 PMID: 27881781
Bruzzoni-Giovanelli (2018) Interfering peptides targeting protein-protein interactions: the next generation of drugs? Drug Discov Today 23(2) 272 PMID: 29097277
Yang (2021) Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models. Cell Death Discov. 7(1) 256 PMID: 34548476
Related areas
All peptides >
All protein-protein interaction modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Val-Phe-Gln-Val-Arg-Ala-Arg-Thr-Val-Ala-OH |
| Molecular Weight | 1145.67 |
| Formula | C51H87N17O13 |
| Sequence | VFQVRARTVA |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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