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Products
Pharmacology
Type
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- About Us
- Technical support
- Resources
PDHPS1
Cat. No. PP-350
Structure:
H-Ile-Ala-Thr-Thr-Thr-Ala-Ser-Ala-Ala-Thr-Ala-Ala-Ala-Ile-Gly-Ala-Thr-Pro-Arg-Ala-Lys-OH
Other Names:
Peptide deregulated in hypertrophic scar-1
Activity:
YAP signaling pathway inhibitor
PDHPS1 (peptide deregulated in hypertrophic scar-1) is an endogenous peptide from skin tissue, whose precursor protein is nuclear mitotic apparatus protein 1 (NUMA1), a protein that plays an essential role in the formation and maintenance of the spindle poles and the alignment and the segregation of chromosomes during mitotic cell division. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), increasing phosphorylation of the oncogene Yes-associated protein (YAP), further inactivating YAP and suppressing the expression of its downstream target genes. PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro, induces cell apoptosis in ovarian cancer cells and inhibits ovarian tumour growth in a subcutaneous xenograft mouse model.
Pan et al (2022) Peptide PDHPS1 Inhibits Ovarian Cancer Growth through Disrupting YAP Signaling. Mol Cancer Ther. 21(7) 1160 PMID: 35545004
Related areas
All peptides >
All protein-protein interaction modulators >
All cancer research categories >
Technical Data
| Structure | H-Ile-Ala-Thr-Thr-Thr-Ala-Ser-Ala-Ala-Thr-Ala-Ala-Ala-Ile-Gly-Ala-Thr-Pro-Arg-Ala-Lys-OH |
| Molecular Weight | 1914.05 |
| Formula | C81H143N25O28 |
| Sequence | IATTTASAATAAAIGATPRAK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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