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Products
Pharmacology
Type
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- Technical support
- Resources
TPP-1
Cat. No. PP-280
Structure:
H-Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys-OH
Other Names:
Targeting PD-L1 peptide, TPP-1 peptide
Activity:
Blocks PD-1/PD-L1 interaction
TPP-1 is a peptide identified through bacterial surface display which binds specifically to programmed cell death ligand 1 (PD-L1), and blocks programmed cell death protein 1 (PD-1)/PD-L1 interaction. TPP-1 binds to free PD-L1 and also cells that express PD-L1 on their cell membranes, and can reverse PD-L1 mediated inhibition of T-cell activation, and inhibit human tumour growth via a T-cell–dependent mechanism. In xenograft mouse models, tumour growth in
TPP-1 treated mice was 56% - 71% lower
than that in controls.
Li et al (2018) Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 6(2) 178 PMID: 29217732
Related data
All protein-protein interaction modulators >
All cancer research areas >
Technical Data
| Structure | H-Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys-OH |
| CAS Number | 2426685-25-6 |
| Molecular Weight | 2488.67 |
| Formula | C107H150N34O32S2 |
| Sequence | SGQYASYHCWCWRDPGRSGGSK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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