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Products
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Bak BH3
Cat. No. PP-060
Structure:
H-Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg-OH
Other Names:
Bak BH3 peptide, BAK peptide
Activity:
Bak BH3 sequence that binds to Bcl-xL
Bak BH3 corresponds to amino acids 72 - 87 in the BH3 region of human Bak and is the miminal sequence for binding to Bcl-xL (B-cell lymphoma-extra large), a transmembrane molecule in the mitochondria which is a member of the Bcl-2 family and key regulator of apoptosis. Bak BH3 has high affinity binding to a surface pocket of the Bcl-XL protein that is essential for its death antagonist function. Bcl-2 is a potent suppressor of apoptosis, and its overexpression contributes to tumourigenesis in many types of human cancers.
Sattler et al (1997) Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis. Science 14 Feb 1997 983 PMID: 9020082
Childs et al (2007) Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol. 292(6) H3179-89 PMID: 17307990
Frey et al (2008) Structure–activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement, Eur. J. Medicinal Chemistry, 43(5) 966 PMID: 17692431
Related areas
All peptides >
All protein-protein interaction modulators >
All regulated cell death research categories >
All cancer research categories >
Technical Data
| Structure | H-Gly-Gln-Val-Gly-Arg-Gln-Leu-Ala-Ile-Ile-Gly-Asp-Asp-Ile-Asn-Arg-OH |
| CAS Number | 300349-67-1 |
| Molecular Weight | 1724.93 |
| Formula | C72H125N25O24 |
| Sequence | GQVGRQLAIIGDDINR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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