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7-Transmembrane receptors
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Neuromedin B (porcine)
Neuromedin B (porcine)
Cat. No. BB-010
Structure:
H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Activity:
Mammalian bombesin like peptide
Neuromedin B (porcine) is a mammalian bombesin like peptide first isolated from pig spinal cord, and is the endogenous ligand for the neuromedin B receptor. Neuromedin B (porcine) is found in the central nervous system as well as in the gastrointestinal tract, the physiological effects of neuromedin B (porcine) include regulation of exocrine and endocrine secretions, as well as smooth muscle contraction, feeding, blood pressure, blood glucose, body temperature and cell growth.
Ohki-Hamazaki et al (2000) Neuromedin B. Prog.Neurobiol. 62 297 PMID: 10840151
Jensen et al (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev. 60(1) 1 PMID: 18055507
Gajjar and Patel (2017) Neuromedin: An insight into its types, receptors and therapeutic opportunities. Pharmacol Rep. 69(3) 438 PMID: 28315588
Related areas
All peptides >
All bombesin receptor modulators >
All neuroscience research categories >
All endocrinology research categories >
All appetite regulation research categories >
Technical Data
| Structure | H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2 |
| CAS Number | 87096-84-2 |
| Molecular Weight | 1132.3 |
| Formula | C52H73N15O12S |
| Sequence | GNLWATGHFM-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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