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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Nociceptin
Cat. No. PN-010
Structure:
H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
Other Names:
Orphanin FQ
Activity:
Endogenous nociceptin receptor agonist
Nociceptin/orphanin FQ (N/OFQ) is a 17-amino acid neuropeptide and an endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin is derived from the prepronociceptin protein, as also are nocistatin and NocII, which inhibit N/OFQ receptor function. The name ‘nociceptin’ derives from the discovery that it can produce a pro-nociceptive response, and nociceptin acts as an anti-analgesic, counteracting the effect of pain-relievers. Nociceptin is widely distributed in the CNS and acts on numerous brain activities including pain sensation and fear. When administered to the spinal cord, nociceptin produces similar analgesic effects to the classical opioids.
Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 532 PMID: 7566152
Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 270 792 PMID: 7481766
Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 18 293 PMID: 9277133
Related areas
All peptides >
All nociceptin receptor modulators >
All pain research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH |
| CAS Number | 170713-75-4 |
| Molecular Weight | 1809.0 |
| Formula | C79H129N27O22 |
| Sequence | FGGFTGARKSARKLANQ |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid and physiological buffers. Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
Batch Specific Data
| Purity | ≥95% by HPLC |
| Safety Data Sheet | Nociceptin MSDS_602c02359afdd.pdf |
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