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Products
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Obestatin (rat)
Cat. No. GH-130
Structure:
H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
Activity:
Hormone which can suppress food intake
Similarly to ghrelin, obestatin is derived from the proteolytic cleavage of proghrelin and binds to the orphan G protein-coupled receptor GPR39 to suppress food intake, inhibit jejunal contraction and decrease body-weight gain in rats, contrary to the appetite-stimulating effects of ghrelin. Thus two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene.
Zhang et al (2005) Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310 996 PMID: 16284174
Nogueiras and Tschop (2005) Biomedicine. Separation of conjoined hormones yields appetite rivals. Science 310 985 PMID: 16284170
Pan and Kastin (2006) Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 27 911 PMID: 16476508
Related areas
All peptides >
All orphan 7-TM receptor modulators >
All appetite regulation research categories >
All endocrinology research categories >
Technical Data
| Structure | H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2 |
| CAS Number | 869705-22-6 |
| Molecular Weight | 2516.8 |
| Formula | C114H174N34O31 |
| Sequence | FNAPFDVGIKLSGAQYQQHGRAL-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dessicated and frozen in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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