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SFFLRN-NH2
Cat. No. PR-110
Structure:
H-Ser-Phe-Phe-Leu-Arg-Asn-NH2
Other Names:
SFLLRN-amide
Activity:
Protease activated receptor-1 (PAR-1) activator
SFFLRN-NH2 is the tethered ligand domain sequence of murine protease-activated receptor-1 (PAR-1), the G protein-coupled receptor highly expressed in platelets and endothelial cells and one of four protease-activated receptors involved in the regulation of the thrombotic response. SFFLRN-NH2 activates PAR-1 and induces relaxant responses of mouse isolated tracheal smooth muscle preparations which are mediated by prostaglandins.
Lan et al (2000) Modulation of airway smooth muscle tone by protease activated receptor-1,-2,-3 and -4 in trachea isolated from infuenza A virus-infected mice. Br. J. Pharmacol. 129 63 PMID: 10694203
Lan et al (2001) Role of PGE2 in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea. Br. J. Pharmacol. 132 93 PMID: 11156565
Related data
All peptides >
All protease activated receptors >
All cardiovascular research categories >
Technical Data
| Structure | H-Ser-Phe-Phe-Leu-Arg-Asn-NH2 |
| Molecular Weight | 781.90 |
| Formula | C37H55N11O8 |
| Sequence | SFFLRN-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water to 1mg per ml |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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