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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Tat (48-60)
Cat. No. CP-010
Structure:
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH
Other Names:
HIV-1 Tat (48 - 60)
Activity:
Cell penetrating cationic peptide derived from the N-terminus of the Tat protein
Tat (48 - 60), also known as HIV-1 Tat (48 - 60), is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a transactivator of the transcription protein present in the human immunodeficiency virus (HIV). Tat (48-60) is an arginine-rich basic peptide which has three domains that function to aid HIV through transactivation, DNA binding and nuclear transport. Tat (48-60) posseses antibacterial activity but is mainly used for the non disruptive transport of exogenous macromolecules into cells.
Futaki (2005) Membrane-permeable arginine-rich peptides and the translocation mechanisms. Adv. Drug Deliv Rev. 57(4) 547 PMID: 15722163
Dennison et al (2007) Interactions of cell penetrating peptide Tat with model membranes: A biophysical study. Biochem. Biophys. Res. Commun. 363(1) 178 PMID: 17854767
Zhu and Shin (2009) Effects of dimerization of the cell-penetrating peptide Tat analog on antimicrobial activity and mechanism of bactericidal action. J. Pept. Sci. 2009 15(5) 345 PMID: 19206074
Related areas
Technical Data
| Structure | H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH |
| Molecular Weight | 1719 |
| Formula | C70H131N35O16 |
| Sequence | GRKKRRQRRRPPQ |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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