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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
PR9
Cat. No. CP-060
Structure:
H-Phe-Phe-Leu-Ile-Pro-Lys-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH
Other Names:
Pas nona-arginine, FFLIPKG-R9
Activity:
Cell penetrating peptide
PR9 is a peptide comprised of nona-arginine (R9), and a penetration accelerating peptide sequence (Pas) that facilitates escape from endocytic lysosomes. PR9 is able to greatly enhance the delivery of noncovalently associated quantum dots (QDs) into human A549 cells. Mechanistic studies, intracellular trafficking analysis and a functional gene assay show that endocytosis is the main route for intracellular delivery of the PR9/QD complex. The PR9/QD complex is non toxic and so can be used as a safe vector for biomedical applications.
Liu et al (2011) Intracellular delivery of quantum dots mediated by a histidine- and arginine-rich HR9 cell-penetrating peptide through the direct membrane translocation mechanism. Biomaterials 32(13) 3520 PMID: 21329975
Liu et al (2013) Endocytic Trafficking of Nanoparticles Delivered by Cell-penetrating Peptides Comprised of Nona-arginine and a Penetration Accelerating Sequence. PLoS One 8(6) e67100 PMID: 23840594
Related areas
Technical Data
| Structure | H-Phe-Phe-Leu-Ile-Pro-Lys-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH |
| Molecular Weight | 2225.39 |
| Formula | C97H172N44O17 |
| Sequence | FFLIPKGRRRRRRRRR |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried sold |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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