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Capreomycin sulphate
Cat. No. AM-430
Structure:
3,6-diamino-N-[[(8E)-15-amino-11-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide sulphate
Other Names:
Capastat
Activity:
Macrocyclic peptide antibiotic
Capreomycin is a macrocyclic peptide antibiotic that was initially isolated from the bacterium Streptomyces capreolus. Capreomycin binds to bacterial ribosomes and inhibits protein synthesis and is considered bacterostatic rather than bacterocidal. Capreomycin additionally has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Clinically, capreomycin is used as a secondary agent in the treatment of tuberculosis in combination with other antituberculosis agents, and usually for multidrug resistant mycobacterial infections. Capreomycin is available as lyophilized powder for suspension in vials of 1 gram for deep intramuscular or intravenous injection under the trade name of Capastat.
Skinner and Cundliffe (1980) Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them. J Gen Microbiol. 120(1) 95 PMID: 6163840
Garcia-Contreras et al (2007) Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother. 51(8) 2830 PMID: 17517845
Siddiqi et al (2016) Capreomycin inhibits the initiation of amyloid fibrillation and suppresses amyloid induced cell toxicity. Biochim Biophys Acta Proteins Proteom. 1866(4) 549 PMID: 29496560
Laughlin and Conn (2022) Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance. Front Microbiol. 13 961921 PMID: 36033858
Related areas
All antimicrobial peptides >
All immunology research categories >
All neuroscience research categories >
Technical Data
| Structure | 3,6-diamino-N-[[(8E)-15-amino-11-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide sulphate |
| CAS Number | 1405-37-4 |
| Molecular Weight | 638.61 |
| Formula | C19H34N12O11S |
Solubility and Storage
| Solubility | ≥ 37 mg per ml in water |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >99% by hplc |
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