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Products
Pharmacology
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- Technical support
- Resources
Peptide5
Cat. No. PN-020
Structure:
H-Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr-OH
Other Names:
Connexin43 mimetic peptide 5
Activity:
Connexin43 hemichannel blocker
Peptide5, also known as connexin43 mimetic peptide 5, was designed to bind to extracellular regions of the connexin43 (Cx43) protein, and is a blocker of Connexin43 hemichannels. Connexin43 hemichannels in spinal cord astrocytes are implicated in the maintenance of neuropathic pain following peripheral nerve injury and Peptide 5 can reduce swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury. Peptide5 exhibits analgesic effects in models of neuropathic pain.
O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID: 18649176
Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp.Brain.Res. 235 3033 PMID: 28725925
Tonkin et al (2017) Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol. 300 1 PMID: 29055716
Related areas
All peptides >
All gap junction channel modulators >
All pain research categories >
All neuroscience research categories >
All immunology research categories >
Technical Data
| Structure | H-Val-Asp-Cys-Phe-Leu-Ser-Arg-Pro-Thr-Glu-Lys-Thr-OH |
| CAS Number | 916977-43-0 |
| Molecular Weight | 1395.6 |
| Formula | C60H98N16O20S |
| Sequence | VDCFLSRPTEKT |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried sold |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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