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Products
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PP1
Cat. No. PP-530
Structure:
H-Trp-Thr-Cys-Cys-His-Gln-Gln-Ala-Glu-Lys-Lys-His-Lys-Thr-Pro-Pro-Tyr-Lys-Phe-Ile-His-Met-OH
Activity:
Inhibits the interaction of Syt11 with vti1a/vti1b
PP1 is a peptide derived from the the linker domain of synaptotagmin-11 (Syt11), which competitively inhibits the interaction of Syt11 with its direct binding proteins vps10p-tail-interactor-1a (vti1a) and vti1b. Synaptotagmin-11 is a non-Ca2+-binding Syt associated with Parkinson's disease and schizophrenia and Syt11 is the most abundantly expressed isoform of the Syt family in microglia, essential for brain development. Syt11 inhibits microglial activation in vivo and application of PP1 induces more cytokine secretion in wildtype microglia upon LPS treatment, phenocopying defects in Syt11 knockdown cells, consistent with the mechanism of regulation of cytokine release by Syt11 being mediated by its interactions with vti1a/vti1b.
Zhang et al (2023) Synaptotagmin-11 regulates immune functions of microglia in vivo. J Neurochem. 167(5) 680 PMID: 37924268
Related areas
All peptides >
All protein-protein interaction modulators >
All neuroscience research categories >
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Technical Data
| Structure | H-Trp-Thr-Cys-Cys-His-Gln-Gln-Ala-Glu-Lys-Lys-His-Lys-Thr-Pro-Pro-Tyr-Lys-Phe-Ile-His-Met-OH |
| Molecular Weight | 2740.32 |
| Formula | C124H185N35O30S3 |
| Sequence | WTCCHQQAEKKHKTPPYKFIHM |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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