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DPN
Cat. No. NR-230
Structure:
2,3-bis(4-Hydroxyphenyl)propionitrile
Other Names:
Diarylpropionitrile
Activity:
ERβ receptor agonist
DPN is a potent estrogen ERβ receptor agonist with 70-fold selectivity over ERα, at each of which it has EC50 values of 0.85 and 66 nM respectively. In vitro, DPN is able to relax mesenteric arteries and can regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus. DPN stimulates proliferation of the androgen-independent prostate cancer cell line PC-3 via a novel pathway involving ERβ-mediated activation of β-catenin and promotes the migration and invasion of androgen‑independent DU‑145 prostate cancer cells. In vivo, DPN is able to ameliorate portal hypertension in a carbon tetrachloride induced liver cirrhosis rat model.
Meyers et al (2001) Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem. 44(24) 4230 PMID: 11708925
Waters et al (2009) Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus. Brain Res. 1290 1 PMID: 19596275
Lombardi et al (2016) Estrogen receptor beta (ERβ) mediates expression of β-catenin and proliferation in prostate cancer cell line PC-3. Mol Cell Endocrinol.430 12 PMID: 27107935
Zhang et al (2016) Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis. World J Gastroenterol. 22(18) 4484 PMID: 27182159
Souza (2023) Estrogen receptors regulate galectin‑3 in androgen‑independent DU‑145 prostate cancer cells. Oncol Rep. 49(5) 93 PMID: 36960864
Related areas
All small molecules >
All nuclear receptor modulators >
All endocrinology research categories >
All cancer research categories >
Technical Data
| Structure | 2,3-bis(4-Hydroxyphenyl)propionitrile |
| CAS Number | 1428-67-7 |
| Molecular Weight | 239.27 |
| Formula | C15H13NO2 |
Solubility and Storage
| Solubility | Soluble in DMSO to 25 mg/ml or in ethanol to 20 mg/ml |
| Appearance | Off-white solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by TLC, NMR conforms |
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Recent citations
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