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Products
Pharmacology
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- Technical support
- Resources
RTDLDSLRTYTL
Cat. No. IG-020
Structure:
H-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-Thr-Tyr-Thr-Leu-OH
Activity:
Alpha(v) beta(6) integrin (avb6) inhibitor
RTDLDSLRTYTL is a phage library selected high affinity 12-mer
peptide with high selectivity for alpha(v) beta(6) integrin (avb6). RTDLDSLRTYTL is a selective inhibitor of RGD dependent ligand binding to avb6 in isolated receptor assays with an IC50 of 20 nM, and also in cell adhesion assays with an IC50 of 50 mM. When tested against avb6 binding to immobilized fibronectin, RTDLDSLRTYTL peptide strongly inhibits the avb6 fibronectin interaction with an IC50 of 100 nM. avb6 is a specific receptor for fibronectin which supports epithelial cell proliferation during wound healing and carcinoma progression.
Kraft et al (1999) Definition of an unexpected ligand recognition motif for alphav beta6 integrin. J. Biol. Chem. 274(4) 1979 PMID: 9890954
Pameijer et al (2007) Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor. Can. Gene Ther. 14 91 PMID: 17024231
Related areas
All peptides >
All integrin receptor modulators >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-Thr-Tyr-Thr-Leu-OH |
| Molecular Weight | 1453.61 |
| Formula | C62H104N18O22 |
| Sequence | RTDLDSLRTYTL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | RTDLDSLRTYTL MSDS_602ce43bd4fa0.pdf |
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Recent citations
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