The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Protonectin-F
Cat. No. MO-030
Structure:
H-Ile-Phe-Gly-Thr-Ile-Leu-Gly-Phe-Leu-Lys-Gly-Leu-NH2
Activity:
Antinociceptide peptide from wasp venom
Protonectin-F is a modified peptide based on protonectin peptide from the venom of the wasp Parachartergus fraternus, which exhibits higher antinociceptive activity and less motor impairment than the parent peptide. The activity of protonectin-F is decreased by either of naloxone and AM251, antagonists of opioid and cannabinoid receptors respectively, which are two critical antinociception pathways. Protonectin-F has no activity on the acid-sensing ion channels (ASICs) rat ASIC1a and ASIC1b, human ASIC1a, and rat ASIC2a. In vivo, in a murine thermal pain induction model, protonectin-F had an antinociceptive effect comparable to morphine at same dose, while inducing less tolerance in after repeated administration.
Galante et al (2023) Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Sci Rep. 13(1) 12491 PMID: 37528129
Related areas
All peptides >
All opioid receptor modulators >
All cannabinoid receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Ile-Phe-Gly-Thr-Ile-Leu-Gly-Phe-Leu-Lys-Gly-Leu-NH2 |
| Molecular Weight | 1276.79 |
| Formula | C64H104N14O13 |
| Sequence | IFGTILGFLKGL-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2025 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio