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Products
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- Resources
NK20a
Cat. No. CY-080
Structure:
H-Asn-Met-Leu-Arg-Asn-Leu-Arg-Asn-Ala-Phe-Ser-Arg-Val-Lys-Thr-Phe-Phe-Gln-Met-Lys-OH
Other Names:
IL-10 inhibitory peptide
Activity:
IL-10 antagonist
NK20a is a peptide designed from the structure of the complex of interleukin-10 (IL-10) with IL-10Ra, the ligand binding subunit of the IL-10 receptor. NK20a has excellent specific affinity for IL-10Ra and can function as an IL-10 antagonist. IL-10 is an immune regulatory cytokine with immunosuppressive and anti-inflammatory activity produced by various cells, including T cells, B cells, keratinocytes, mast cells, eosinophils, dendritic cells, monocytes, and macrophages, and it is upregulated in various cancers. In vitro, NK20a exerts anticancer effects on lymphoma B cells and can abolish the suppression effect of IL-10 on macrophages, consistent with the idea that blockade of the IL-10 receptor inhibits cell proliferation and survival. NK20a can also be conjugated with gold nanoparticles to enhance the anticancer efficacy of 5-fluorouracil (5-FU) against the breast cancer cell line BT-474.
Chang et al (2023) A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics. Commun Chem. 6(1) 278 PMID: 38102207
Related areas
All peptides >
All cytokine receptor modulators >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Asn-Met-Leu-Arg-Asn-Leu-Arg-Asn-Ala-Phe-Ser-Arg-Val-Lys-Thr-Phe-Phe-Gln-Met-Lys-OH |
| Molecular Weight | 2500.33 |
| Formula | C111H181N35O27S2 |
| Sequence | NMLRNLRNAFSRVKTFFQMK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | > 95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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