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Products
Pharmacology
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CD36 peptide
Cat. No. PP-510
Structure:
H-Tyr-Arg-Val-Arg-Phe-Leu-Ala-Lys-Glu-Asn-Val-Thr-Gln-Asp-Ala-Glu-Asp-Asn-OH
Other Names:
Thrombospondin1 antagonist peptide, CD36 peptide (93–110), P93-110
Activity:
Blocks CD36 - thrombospondin1 association
CD36 peptide is derived from CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4 or fatty acid translocase (FAT), a plasma membrane protein of wide cellular distribution which functions as a receptor for thrombospondin (TSP). CD36 peptide blocks binding of CD36 to TSP and partially inhibits collagen induced platelet aggregation, but does not itself bind to TSP. TSP1 plays a pivotal role in obesity related inflammation and insulin resistance by modulating macrophage accumulation and activation in adipose tissue, and CD36 peptide, functioning as a TSP1 antagonist, effectively inhibits this activation. In an obese mouse model, CD36 peptide treatment does not affect obesity or weight gain but attenuates systemic inflammation and reduces proinflammatory cytokine production. CD36 peptide treatment improves glucose tolerance and insulin sensitivity and mitigates obesity related fatty liver disease and kidney damage.
Leung et al (1992) CD36 peptides enhance or inhibit CD36-thrombospondin binding. A two-step process of ligand-receptor interaction. J Biol Chem. 267(25) 18244 PMID: 1381367
Li et al (2013) Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway. Cell Mol Immunol. 10(6) 506 PMID: 23954950
Zhou et al (2023) Thrombospondin1 antagonist peptide treatment attenuates obesity-associated chronic inflammation and metabolic disorders in a diet-induced obese mouse model. Sci Rep. 13(1) 20193 PMID: 37980376
Related areas
All peptides >
All protein-protein interaction modulators >
All immunology research categories >
All diabetes research categories >
Technical Data
| Structure | H-Tyr-Arg-Val-Arg-Phe-Leu-Ala-Lys-Glu-Asn-Val-Thr-Gln-Asp-Ala-Glu-Asp-Asn-OH |
| Molecular Weight | 2167.07 |
| Formula | C93H146N28O32 |
| Sequence | YRVRFLAKENVTQDAEDN |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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