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PS18
Cat. No. OR-040
Structure:
H-Leu-Ser-Glu-Leu-Ile-Ile-Asn-Asn-Ala-Thr-Glu-Glu-Leu-Leu-Ile-Lys-Gly-Leu-OH
Other Names:
Prosaposin PS18
Activity:
Neurotrophic and neuroprotective
PS18 is a peptide derived from the NH2-terminal hydrophilic sequence of the rat saposin C-domain. Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties, and PS18 mimics the trophic activity of full length prosaposin. PS18 is neuroprotective in cellular and animal models of Parkinsons disease, and in a rat Alzheimer model, PS18 attenuates Aβ1-42-induced neuroinflammation and prevents memory deficits. In gerbils, PS18 protects against ischemia induced learning disability and neuronal loss, and improves behavioural deficits and enhances survival of neurons against neurotoxicity induced by kainic acid. The mechanism of action of PS18 is complex, it activates the PI3K/Akt pathway, phosphorylates GSK-3α/β, suppresses the caspase pathway; upregulates Bcl-2 and downregulates BAX. The receptors for prosaposin are proposed to be GPR37 and GPR37L1.
Kotani et al (1996) A hydrophilic peptide comprising 18 amino acid residues of the prosaposin sequence has neurotrophic activity in vitro and in vivo. J Neurochem. 66(5) 2197 PMID: 8780053
Nabeka et al (2015) A prosaposin-derived Peptide alleviates kainic Acid-induced brain injury. PLoS One 10(5) e0126856 PMID: 25993033
Gao et al (2016) An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1-42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice. J Alzheimers Dis. 53(3) 1173 PMID: 27372641
Wu (2023) Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease. Sci Rep. 13(1) 8148 PMID: 37208379
Related areas
All peptides >
All orphan 7-TM receptor modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Leu-Ser-Glu-Leu-Ile-Ile-Asn-Asn-Ala-Thr-Glu-Glu-Leu-Leu-Ile-Lys-Gly-Leu-OH |
| Molecular Weight | 1982.13 |
| Formula | C89H155N21O29 |
| Sequence | LSELIINNATEELLIKGL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Certificate of Analysis | OR-040-1MG PS18 certificate of Analysis_66796011cddd5.pdf |
| Safety Data Sheet | OR-040 VPM-p15 SDS_667c2be1dc4d2.pdf |
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Recent citations
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